Benzothiazole Derivatives of Chitosan and Their Derived Nanoparticles: Synthesis and In Vitro and In Vivo Antibacterial Effects

In this work, we focused on synthesizing and assessing novel chitosan-based antibacterial polymers their nanoparticles by incorporating benzothiazole substituents. The growing resistance to antibiotics has necessitated the search for alternative antimicrobial compounds. This study aimed synthesize evaluate with substituents properties toxicity. derivatives of chitosan were synthesized through electrochemical coupling. in vivo efficacy was tested white rats induced peritonitis using a microbial suspension containing S. aureus E. coli. Additionally, vitro toxicity assessments conducted. systems showed significant activity, surpassing that unmodified commercial antibiotics. Moreover, studies revealed low levels derivatives, which did not differ significantly from native chitosan. demonstrated potent activity toxicity, highlighting potential as effective alternatives traditional Further investigations pharmacology preclinical trials are recommended explore application clinical settings.